AMPA Receptors Unbound
نویسندگان
چکیده
منابع مشابه
AMPA Receptors Unbound Membrane Cycling and Synaptic Plasticity
will diffuse freely until they are trapped and stabilized How does one modify the strength of a synapse? On at synaptic sites through association with multiprotein first inspection, this is a deceptively straightforward complexes that anchor them to the cytoskeleton. These question. After all, the strength of a synaptic connection anchoring proteins include a number of PDZ domain– between two n...
متن کاملGating modes in AMPA receptors.
AMPA receptors are ligand-gated ion channels that show multiple conductance levels, indicating that gating of individual AMPA subunits is to some extent independent of the other subunits. To study AMPAR subunit interactions during activation gating, we recorded from single channels in the absence of channel block and desensitization and at negative and positive membrane potentials. In saturatin...
متن کاملNomadic AMPA Receptors and LTP
leased glutamate could explain the electrophysiological changes observed during LTP that have been attributed to an increase in presynaptically released neurotrans-Long-term potentiation (LTP) is one of the most widely mitters. In support of the silent synapse hypothesis, studied topics in neuroscience today. LTP refers to a electrophysiological and immunohistochemical studies long-lasting incr...
متن کاملModulating AMPA receptors makes memories special
Tumor cells: a single signal to divide and conquer? etastatic tumor cells are dangerous because they not only proliferate but also migrate and invade other tissues. On page 817, Manes et al. reach the surprising conclusion that the cyclin-dependent kinase cdc2 regulates both of these activities. The work identifies a novel signaling pathway and points to a promising new strategy for targeting m...
متن کاملUbiquitin signals the demise of AMPA receptors
Efficient communication between neurons is essential for all activities ranging from muscle movement and motor coordination to higher-order information processing and cognitive functions such as learning and memory. The majority of fast excitatory synaptic transmission in the mammalian central nervous system is mediated by the release of glutamates from the presynaptic terminal and their bindin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuron
سال: 2000
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(00)81131-9